- Do a throat culture for Group A B-Hemolytic Strep
- Do a blood test to check for elevated antibody levels against the following streptococcal, B-cell and brain antigens:
1. Antibodies to the extra cellular products of Group A Streptococci which collectively are named Streptozyme
- Streptolysin O (SO)
- Streptokinase (SK)
- Hyaluronidase (SH)
- Deoxyribonuclease (DNase)
- Nicotinamide Adenine Dinucleotidase (NADase)
2. Antibodies to streptococcal cell components
- M5 peptide
- M12 peptide
- M19 peptide
3. Antibodies to B-cell autoantigen
- D8/17
4. Anti-brain antibodies
- Myelin basic protein
- Ganglioside (Asialoganglioside GM1)
What to do if you suspect PANDAS:
- Do a throat culture for Group A B-Hemolytic Strep
- Do a blood test to check for elevated antibody levels against the following streptococcal, B-cell and brain antigens:
1. Antibodies to the extra cellular products of Group A Streptococci which collectively are named Streptozyme
- Streptolysin O (SO)
- Streptokinase (SK)
- Hyaluronidase (SH)
- Deoxyribonuclease (DNase)
- Nicotinamide Adenine Dinucleotidase (NADase)
2. Antibodies to streptococcal cell components
- M5 peptide
- M12 peptide
- M19 peptide
3. Antibodies to B-cell autoantigen
- D8/17
4. Anti-brain antibodies
- Myelin basic protein
- Ganglioside (Asialoganglioside GM1)